FastBMD: an online tool for rapid benchmark dose-response analysis of transcriptomics data
Transcriptomics dose-response analysis is a promising new approach method for toxicity testing. While international regulatory agencies have spent substantial effort establishing a standardized statistical approach, existing software that follows this approach is computationally inefficient and must be locally installed.
FastBMD is a web-based tool that implements standardized methods for transcriptomics benchmark dose-response analysis in R. It is > 60 times faster than the current leading software, supports transcriptomics data from 13 species, and offers a comprehensive analytical pipeline that goes from processing and normalization of raw gene expression values to interactive exploration of pathway-level benchmark dose results.
FastBMD is freely available at www.fastbmd.ca
Supplementary data are available at Bioinformatics online.
Ewald, J.D., Soufan, O., Xia, J., Basu, N. 2020. FastBMD: an online tool for rapid benchmark dose-response analysis of transcriptomics data. Bioinformatics, btaa700, https://doi.org/10.1093/bioinformatics/btaa700.