FastBMD: an online tool for rapid benchmark dose-response analysis of transcriptomics dataMotivation
Transcriptomics dose-response analysis is a promising new approach method for toxicity testing. While international regulatory agencies have spent substantial effort establishing a standardized statistical approach, existing software that follows this approach is computationally inefficient and must be locally installed. Results FastBMD is a web-based tool that implements standardized methods for transcriptomics benchmark dose-response analysis in R. It is > 60 times faster than the current leading software, supports transcriptomics data from 13 species, and offers a comprehensive analytical pipeline that goes from processing and normalization of raw gene expression values to interactive exploration of pathway-level benchmark dose results. Availability FastBMD is freely available at www.fastbmd.ca Supplementary information Supplementary data are available at Bioinformatics online. https://pubs.acs.org/doi/abs/10.1021/acs.est.9b06607 |
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Ewald, J.D., Soufan, O., Xia, J., Basu, N. 2020. FastBMD: an online tool for rapid benchmark dose-response analysis of transcriptomics data. Bioinformatics, btaa700, https://doi.org/10.1093/bioinformatics/btaa700.