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FastBMD: an online tool for rapid benchmark dose-response analysis of transcriptomics data

Motivation
Transcriptomics dose-response analysis is a promising new approach method for toxicity testing. While international regulatory agencies have spent substantial effort establishing a standardized statistical approach, existing software that follows this approach is computationally inefficient and must be locally installed.

Results
FastBMD is a web-based tool that implements standardized methods for transcriptomics benchmark dose-response analysis in R. It is > 60 times faster than the current leading software, supports transcriptomics data from 13 species, and offers a comprehensive analytical pipeline that goes from processing and normalization of raw gene expression values to interactive exploration of pathway-level benchmark dose results.

Availability
FastBMD is freely available at www.fastbmd.ca

Supplementary information
Supplementary data are available at Bioinformatics online.

https://pubs.acs.org/doi/abs/10.1021/acs.est.9b06607
Picture
Ewald, J.D., Soufan, O., Xia, J., Basu, N. 2020. FastBMD: an online tool for rapid benchmark dose-response analysis of transcriptomics data. ​​​Bioinformatics, btaa700, https://doi.org/10.1093/bioinformatics/btaa700.
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