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EcoToxChips mentioned in ECCC Biological Test MethodBiological test method : toxicity tests using aquatic life stages of frogs (Lithobates pipiens) / Method Development and Applications Unit, Science and Technology Branch, Environment and Climate Change Canada. STB 1/RM/62. April 2024.
The report mentions EcoToxChips as a "non-traditional endpoint" and that "Tissue samples can also be collected for EcoToxChips, a next-generation toxicogenomics tool that can be used to identify specific molecular mechanisms of action for the assessment of chemicals of concern and environmental management (Basu et al., 2019; Crump et al., 2023). |
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EcoToxChip approach to validation highlighted in European Chemicals Agency report"EcoToxChip Test System may have the potential to prioritize chemicals for management and further testing the effects on growth, survival, reproduction of fish, amphibians and birds. A validation exercise has been launched recently in ENV Canada to investigate its use in regulatory context (Validation of the use of the EcoToxChip test system for regulatory decision-making (genomequebec.com). Similar exercise could be done for REACH substances"
November 2023 |
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An investment of nearly $16.5 million for health and environmental solutionsGénome Québec
April 18, 2023 "This project aims to advance the existing EcoToxChip Test System so that it can be accessible, while also being consistent and reliable for informing regulatory decisions. The goal is, in partnership with Environment and Climate Change Canada’s Science and Technology Branch, to validate these tools for use in a range of prioritization and assessment activities under Canada’s Chemicals Management Plan... This new made-in-Canada tool will reduce the cost and time for chemical testing as well as boost Canadian leadership in this area." |
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NAMs for the Endocrine Activity ToolboxEnvironmental Toxicology and Chemistry. Vol 42. 2023.
"There have also been efforts to develop and standardize reduced transcriptome panels that are representative of diverse biological pathways of interest from a toxicological perspective... One such example are EcoToxChips, which use early, non-protected vertebrate embryonic life stages" |
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Ecotoxicology assessments in avian species using cell-base models: A review.Avian Biology. 2021.
“The AvianToxChip/EcoToxChip modeling is a project to keep an eye on over the next several years. The data is still being developed for the database. If it works out as predicted, the database will be a valuable tool to avian researchers and greatly expand predictive modeling.” |
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New technology could drastically reduce live animal testingSaskatoon Star Phoenix
May 7, 2019 Footage with Markus Hecker at UofS lab explaining the EcoToxChip technology
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